?Quality control standardization of Indonesian noni fruit (Morinda citrifolia) extract and evaluation of their angiotensin-converting enzyme inhibitory activity
نویسندگان
چکیده
Morinda citrifolia fruit (Noni) has been used as a folk medicine in several countries. Noni possessed various pharmacological activities such as; anticancer, antidiabetic, antihypertensive, antarthritic, and antioxidants. The present study evaluated pharmacognostic properties, profiling of active constituent through High-Performance Thin Layer Chromatography (HPTLC) Liquid Chromatography-High Resolution Mass Spectrometer (LC-HRMS) run for quantitative qualitative phytochemical analysis determining angiotensin-converting enzyme (ACE) inhibitor activity from three different locations. physicochemical parameters crude drugs extracts met the requirement Indonesian Herbal Pharmacopeia. Total phenol content was 2.16-3.08 mg GAE/g extract total flavonoid 0.11 - 1.58 QE/g extract. HPTLC revealed that scopoletin range 0.44 0.51%. results were also corresponding well with LC-HRMS fingerprint analysis. In addition, Bogor potential exhibited inhibiting ACE an IC50 value 206.26 µg/mL.
منابع مشابه
Noni (Morinda citrifolia).
Noni is an evergreen plant prevalent in Southeast Asia, Australia, and the Polynesian islands. It is used in traditional medicine for wound healing, infections, skin conditions, diarrhea, and as a tonic. Noni products have gained worldwide popularity over the past 2 decades and are aggressively marketed for immunostimulation and for treatment of chronic fatigue syndrome and cancer. Preliminary ...
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ژورنال
عنوان ژورنال: ????????
سال: 2022
ISSN: ['2411-6076', '2709-135X']
DOI: https://doi.org/10.3897/pharmacia.69.e86854